Failure to unwind causes cancer. Genome stability

Curr Biol. 1996 Mar 1;6(3):265-7. doi: 10.1016/s0960-9822(02)00474-8.

Abstract

The recent cloning of the gene defective in individuals with Bloom's syndrome has revealed a link between DNA helicases, genetic instability and a predisposition to cancer.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / chemistry
  • Adenosine Triphosphatases / metabolism*
  • Bloom Syndrome / enzymology*
  • Bloom Syndrome / genetics
  • DNA Helicases / chemistry
  • DNA Helicases / genetics
  • DNA Helicases / metabolism*
  • Genetic Predisposition to Disease
  • Genome
  • Humans
  • Neoplasms / enzymology*
  • Neoplasms / genetics
  • RecQ Helicases
  • Saccharomyces cerevisiae Proteins

Substances

  • Saccharomyces cerevisiae Proteins
  • Adenosine Triphosphatases
  • Bloom syndrome protein
  • RECQL protein, human
  • SGS1 protein, S cerevisiae
  • DNA Helicases
  • RecQ Helicases