Activity of glycylcyclines CL 329998 and CL 331002 against minocycline-resistant and other strains of methicillin-resistant Staphylococcus aureus

J Antimicrob Chemother. 1996 Jun;37(6):1171-5. doi: 10.1093/jac/37.6.1171.

Abstract

Two glycylcyclines have been tested against 191 strains of methicillin-resistant Staphylococcus aureus, 72 of which were resistant to minocycline, isolated from many parts of the world. MICs of CL 329998 ranged from 0.06 to 4 mg/L, with MIC50 and MIC90 0.5 and 2 mg/L, respectively. CL 331002 was slightly less potent, having an MIC range 0.12-16 mg/L and MIC50 and MIC90 values of 1 and 4 mg/L, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Americas
  • Anti-Bacterial Agents / pharmacology
  • Asia
  • Bacterial Proteins / genetics
  • Europe
  • Membrane Proteins / genetics
  • Methicillin Resistance*
  • Microbial Sensitivity Tests
  • Minocycline / analogs & derivatives*
  • Minocycline / pharmacology*
  • Phenotype
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / genetics
  • Tetracycline Resistance / genetics
  • Tetracyclines / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Membrane Proteins
  • Tet M resistance protein, Bacteria
  • Tetracyclines
  • tet(K) protein, Staphylococcus aureus
  • CL 331002
  • N,N-dimethylglycylamidominocycline
  • Minocycline