Abstract
Two glycylcyclines have been tested against 191 strains of methicillin-resistant Staphylococcus aureus, 72 of which were resistant to minocycline, isolated from many parts of the world. MICs of CL 329998 ranged from 0.06 to 4 mg/L, with MIC50 and MIC90 0.5 and 2 mg/L, respectively. CL 331002 was slightly less potent, having an MIC range 0.12-16 mg/L and MIC50 and MIC90 values of 1 and 4 mg/L, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Americas
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Anti-Bacterial Agents / pharmacology
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Asia
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Bacterial Proteins / genetics
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Europe
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Membrane Proteins / genetics
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Methicillin Resistance*
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Microbial Sensitivity Tests
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Minocycline / analogs & derivatives*
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Minocycline / pharmacology*
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Phenotype
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / genetics
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Tetracycline Resistance / genetics
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Tetracyclines / pharmacology*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Membrane Proteins
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Tet M resistance protein, Bacteria
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Tetracyclines
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tet(K) protein, Staphylococcus aureus
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CL 331002
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N,N-dimethylglycylamidominocycline
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Minocycline