Molecular cloning of the N-terminus of GTBP

Genomics. 1996 Feb 1;31(3):395-7. doi: 10.1006/geno.1996.0067.

Abstract

Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5' terminus, allowing definition of the entire coding region. Several polymorphisms within the 5' end were identified and are presented.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular
  • DNA
  • DNA-Binding Proteins / genetics*
  • HeLa Cells
  • Humans
  • Molecular Sequence Data
  • Polymorphism, Genetic

Substances

  • DNA-Binding Proteins
  • G-T mismatch-binding protein
  • DNA

Associated data

  • GENBANK/U28946