Abstract
Transcription initiation on protein-encoding genes represents a major control point for gene expression in eukaryotes, and is mediated by RNA polymerase II and a surprisingly complex array of general initiation factors (TFIIA, -B, -D, -E, -F and -H) that are highly conserved from yeast to man. Elucidation of structural and functional features of these factors on model promoters has revealed insights into biochemical mechanisms and provides a basis for understanding their regulation on diverse promoters by gene- and cell-specific activators.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
DNA-Binding Proteins / genetics
-
Forecasting
-
Humans
-
Models, Genetic
-
Promoter Regions, Genetic
-
RNA Polymerase II / chemistry
-
RNA Polymerase II / genetics*
-
RNA Polymerase II / metabolism*
-
TATA Box
-
TATA-Box Binding Protein
-
Transcription Factor TFIIA
-
Transcription Factor TFIIB
-
Transcription Factors / genetics*
-
Transcription Factors / metabolism
-
Transcription, Genetic*
Substances
-
DNA-Binding Proteins
-
TATA-Box Binding Protein
-
Transcription Factor TFIIA
-
Transcription Factor TFIIB
-
Transcription Factors
-
RNA Polymerase II