Expression, regulation and polymorphism of the mxi1 genes

Gene. 1996 Oct 17;176(1-2):45-8. doi: 10.1016/0378-1119(96)00206-5.

Abstract

The myc proto-oncogene family plays an important role in the control of cellular growth and differentiation. Mxi1, one of the Max-associated proteins, has been known to have an antagonistic action on Myc activity. The mxi1 mRNA increased during growth inhibition and differentiation, and decreased with serum stimulation in mammal cell lines. We have also found an AAAAC polymorphic repeat in the 3' non-coding region of the human mxi1 cDNAs and a difference between the mxi1 mRNA half-lives in some different cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Basic Helix-Loop-Helix Transcription Factors
  • Cell Differentiation
  • Cell Division
  • DNA, Complementary
  • DNA-Binding Proteins / genetics*
  • Gene Expression Regulation*
  • Humans
  • Microsatellite Repeats
  • Molecular Sequence Data
  • Polymorphism, Genetic*
  • Proto-Oncogene Mas
  • RNA, Messenger
  • Transcription Factors / genetics*
  • Tumor Cells, Cultured
  • Tumor Suppressor Proteins

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • DNA, Complementary
  • DNA-Binding Proteins
  • MAS1 protein, human
  • MXI1 protein, human
  • Proto-Oncogene Mas
  • RNA, Messenger
  • Transcription Factors
  • Tumor Suppressor Proteins

Associated data

  • GENBANK/D63940