Host factors and the pathogenesis of HIV-induced disease

Nature. 1996 Dec 12;384(6609):529-34. doi: 10.1038/384529a0.

Abstract

The level of human immunodeficiency virus (HIV) replication in patients reflects a balance between stimulatory and inhibitory host factors (particularly endogenous cytokines). New information concerning the cellular co-receptors for HIV and the cellular tropism of different strains of virus will advance our understanding of HIV-induced pathogenesis and suggests new therapeutic and preventive strategies.

Publication types

  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / virology
  • Cytokines / physiology*
  • Disease Progression
  • HIV / physiology*
  • HIV Infections / immunology*
  • HIV Infections / prevention & control
  • HIV Infections / therapy
  • HIV Infections / transmission
  • HIV Infections / virology*
  • Humans
  • Immunity, Innate
  • Macrophages / virology
  • Monocytes / virology
  • Receptors, Cytokine / genetics
  • Receptors, Cytokine / physiology*
  • Receptors, HIV / genetics
  • Receptors, HIV / physiology*
  • Viremia
  • Virus Replication

Substances

  • Cytokines
  • Receptors, Cytokine
  • Receptors, HIV