Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani

J Nat Prod. 1996 Jan;59(1):27-9. doi: 10.1021/np960018g.

Abstract

A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides: amarogentin (1), amaroswerin (2), and sweroside (3). Amarogentin is a potent inhibitor of type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme, preventing binary complex formation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA, Protozoan / chemistry
  • DNA, Protozoan / drug effects
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology*
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology
  • India
  • Iridoids*
  • Leishmania donovani / enzymology*
  • Magnetic Resonance Spectroscopy
  • Plants, Medicinal / chemistry*
  • Pyrans / chemistry
  • Pyrans / isolation & purification*
  • Pyrans / pharmacology
  • Topoisomerase I Inhibitors*

Substances

  • DNA, Protozoan
  • Enzyme Inhibitors
  • Glucosides
  • Iridoids
  • Pyrans
  • Topoisomerase I Inhibitors
  • amarogentin