Carbamazepine and PIP-syndrome in temporal lobe epilepsy

Epilepsy Res. 1995 Nov;22(3):215-20. doi: 10.1016/0920-1211(95)00038-0.

Abstract

We describe four patients with left temporal lobe epilepsy who developed psychosis, intermittent polydipsia and hyponatremia (PIP-syndrome) while being treated with carbamazepine. These cases illustrate the close links between dysfunction of the limbic system causing epileptic seizures and psychosis on the one hand and dysregulation in hypothalamic centers manifestating in polydipsia and osmodysregulation on the other.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticonvulsants / adverse effects*
  • Carbamazepine / adverse effects*
  • Cholera / complications
  • Craniocerebral Trauma / complications
  • Drinking Behavior / drug effects*
  • Electroencephalography
  • Epilepsy, Temporal Lobe / drug therapy*
  • Epilepsy, Temporal Lobe / psychology
  • Female
  • Humans
  • Hyponatremia / chemically induced*
  • Malaria / complications
  • Male
  • Middle Aged
  • Tomography, X-Ray Computed
  • Water-Electrolyte Balance / drug effects

Substances

  • Anticonvulsants
  • Carbamazepine