Cytokines and their effects on maturation, differentiation and migration of dendritic cells

Arch Dermatol Res. 1996 Dec;289(1):1-8. doi: 10.1007/s004030050144.

Abstract

In this review the role of cytokines in the maturation and migration of phenotypically and functionally diverse dendritic cell (DC) subpopulations is discussed and their role in progress of differentiation from bone marrow progenitors to lymphoid DC is described. GM-CSF is the most important cytokine for the development of functional DC and acts in concert with a varying mixture of other cytokines such as IL-4, IL-1 and TNF-alpha to direct the development of individual DC subpopulations.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation
  • Antigens, Surface / metabolism
  • Cell Differentiation / drug effects
  • Cell Differentiation / immunology
  • Cell Movement / drug effects
  • Cell Movement / immunology
  • Cytokines / pharmacology
  • Cytokines / physiology*
  • Dendritic Cells / cytology*
  • Dendritic Cells / drug effects
  • Dendritic Cells / immunology
  • Humans
  • Langerhans Cells / cytology
  • Langerhans Cells / drug effects
  • Langerhans Cells / immunology
  • Lymphoid Tissue / cytology
  • Lymphoid Tissue / drug effects
  • Lymphoid Tissue / immunology
  • Stem Cells / cytology
  • Stem Cells / drug effects
  • Stem Cells / immunology

Substances

  • Antigens, Surface
  • Cytokines