Abstract
Stimulation of the T-cell receptor complex in resting T cells leads to activation. However, antigenic stimulation of immature T lymphocytes and activated mature T cells results in apoptosis. Recent work suggests that distinct signaling pathways in T cells mediate cell death and cell activation. In this article, genes that are involved in apoptosis of immature T cells and T-cell hybridomas are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Apoptosis / genetics*
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DNA-Binding Proteins / genetics
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Hybridomas
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Ki-1 Antigen / genetics
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Nuclear Receptor Subfamily 4, Group A, Member 1
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Receptors, Antigen, T-Cell / metabolism
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Receptors, Cytoplasmic and Nuclear
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Receptors, Steroid
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Signal Transduction*
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T-Lymphocytes / immunology*
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Thymus Gland / cytology
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Thymus Gland / immunology*
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Transcription Factors / genetics
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fas Receptor / genetics
Substances
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DNA-Binding Proteins
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Ki-1 Antigen
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Nuclear Receptor Subfamily 4, Group A, Member 1
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Receptors, Antigen, T-Cell
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Receptors, Cytoplasmic and Nuclear
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Receptors, Steroid
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Transcription Factors
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fas Receptor