Abstract
The source of the enzyme activity responsible for the transposition of retrotransposons of the type that lack terminal repeats has at last been identified: in L1Hs elements, it is encoded by the second open reading frame and is a nuclease related to the apurinic repair endonucleases.
MeSH terms
-
Animals
-
DNA Repair / genetics
-
DNA-(Apurinic or Apyrimidinic Site) Lyase
-
Deoxyribonuclease IV (Phage T4-Induced)
-
Drosophila melanogaster / genetics
-
Drosophila melanogaster / virology
-
Genes, gag
-
Genes, pol
-
Humans
-
Lyases / metabolism
-
Models, Genetic
-
Moloney murine leukemia virus / genetics
-
Open Reading Frames
-
RNA-Directed DNA Polymerase / metabolism
-
Repetitive Sequences, Nucleic Acid*
-
Retroelements*
-
Retroviridae / genetics*
-
Saccharomyces cerevisiae / genetics
-
Saccharomyces cerevisiae / virology
-
Sequence Deletion
Substances
-
Retroelements
-
RNA-Directed DNA Polymerase
-
Deoxyribonuclease IV (Phage T4-Induced)
-
Lyases
-
DNA-(Apurinic or Apyrimidinic Site) Lyase