Abstract
Methionine adenosyltransferase (MAT) is an ubiquitous enzyme that catalyzes the synthesis of S-adenosylmethionine from methionine and ATP. In mammals, there are two genes coding for MAT, one expressed exclusively in the liver and a second enzyme present in all tissues. Molecular studies indicate that liver MAT exists in two forms: as a homodimer and as a homotetramer of the same oligomeric subunit. The liver-specific isoenzymes are inhibited in human liver cirrhosis, and this is the cause of the abnormal metabolism of methionine in these subjects.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Chemical and Drug Induced Liver Injury
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Gene Expression Regulation, Enzymologic / genetics
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Humans
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Liver / enzymology
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Liver / metabolism*
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Liver / pathology
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Liver Diseases / metabolism
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Liver Diseases / prevention & control
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Methionine / metabolism
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Methionine Adenosyltransferase / chemistry
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Methionine Adenosyltransferase / deficiency
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Methionine Adenosyltransferase / genetics*
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Methylation
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S-Adenosylmethionine / biosynthesis*
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S-Adenosylmethionine / genetics
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S-Adenosylmethionine / physiology
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Species Specificity
Substances
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S-Adenosylmethionine
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Methionine
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Methionine Adenosyltransferase