Abstract
Trefoil factor family (TFF)-domain peptides 1-3 are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Structurally similar, resistant to enzymatic degradation, they are up-regulated around areas of epithelial damage such as ulcers. Transgenic expression or exogenous peptide ameliorates or prevents gastric mucosal damage due to indomethacin and some are rapidly up-regulated after cryogenic burns. A role in promoting cell migration is strongly suggested. Knockout mice lacking TFF1 or TFF3 show significant pathology, with the former developing gastric tumours. A recent Conference Philippe Laudat agreed upon a new nomenclature for these peptides.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Movement*
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Consensus Sequence
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Gastrointestinal Neoplasms / etiology*
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Gastrointestinal Neoplasms / pathology
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Growth Substances / chemistry
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Growth Substances / metabolism*
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Indomethacin / toxicity
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Intestinal Mucosa / chemistry
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Intestinal Mucosa / cytology
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Intestinal Mucosa / metabolism*
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Mice
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Mice, Knockout
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Mucins*
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Muscle Proteins*
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Neuropeptides / chemistry
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Neuropeptides / metabolism
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Peptides / chemistry
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Peptides / metabolism*
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Terminology as Topic
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Trefoil Factor-2
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Trefoil Factor-3
Substances
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Growth Substances
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Mucins
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Muscle Proteins
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Neuropeptides
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Peptides
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TFF3 protein, rat
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Trefoil Factor-2
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Trefoil Factor-3
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Indomethacin