Cloning, characterization, and chromosomal localization of human liver form cytochrome c oxidase subunit VIa related genes

Genome. 1997 Jun;40(3):325-31. doi: 10.1139/g97-045.

Abstract

The chromosomal location of human cytochrome c oxidase (COX) subunit VIa Liver (VIa-L) isoform related sequences has been determined by a combination of in situ hybridization and analysis of human-hamster somatic cell hybrid panels. COX VIa-L related sequences were present on chromosomes 6 and 12. It has been verified that at least two COX VIa-L genes are on chromosome 6, one of which is a pseudogene. In total, four COX VIa-L related sequences have been cloned and their nucleotide sequences analyzed. At least three of the sequences represent pseudogenes; their relatedness to the COX VIa-L cDNA is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Blotting, Southern
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 12
  • Chromosomes, Human, Pair 6
  • Cloning, Molecular
  • Cricetinae
  • Electron Transport Complex IV / genetics*
  • Humans
  • Hybrid Cells
  • Isoenzymes
  • Liver / enzymology*
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Pseudogenes*
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid
  • Species Specificity

Substances

  • Isoenzymes
  • Electron Transport Complex IV