Effect of chronic clozapine administration on [3H]MK801-binding sites in the rat brain: a side-preference action in cortical areas

Brain Res. 1997 Jul 11;762(1-2):216-8. doi: 10.1016/s0006-8993(97)00478-2.

Abstract

We studied modifications in [3H]MK801-binding sites in the rat brain after chronic clozapine. We found a 20-30% reduction of [3H]MK801-binding sites in the anterior cingulate, frontoparietal motor and frontoparietal somatosensory cortices on the left side but none on the right. We also demonstrated a 20% bilateral increase of N-methyl-D-aspartate (NMDA) receptors in the dentate gyrus of the hippocampus. No changes were found in the prefrontal cortex, caudate-putamen, nucleus accumbens, hippocampus or olfactory tubercle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antipsychotic Agents / pharmacology*
  • Autoradiography
  • Binding Sites / physiology
  • Brain Chemistry / physiology
  • Cerebral Cortex / chemistry*
  • Cerebral Cortex / metabolism
  • Clozapine / pharmacology*
  • Dizocilpine Maleate / metabolism
  • Dizocilpine Maleate / pharmacology*
  • Excitatory Amino Acid Antagonists / metabolism
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
  • Time Factors
  • Tritium

Substances

  • Antipsychotic Agents
  • Excitatory Amino Acid Antagonists
  • Receptors, N-Methyl-D-Aspartate
  • Tritium
  • Dizocilpine Maleate
  • Clozapine