Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization

M A van Kuijck; M Kool; G F Merkx; A Geurts van Kessel; R J Bindels; P M Deen; C H van Os

doi:10.1159/000134599

Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization

Cytogenet Cell Genet. 1997;77(3-4):285-7. doi: 10.1159/000134599.

Authors

M A van Kuijck¹, M Kool, G F Merkx, A Geurts van Kessel, R J Bindels, P M Deen, C H van Os

Affiliation

¹ Department of Cell Physiology, University of Nijmengen, The Netherlands. m.vankuijclk@celfys.kun.nl

PMID: 9284939
DOI: 10.1159/000134599

Abstract

Rabbit epithelial basolateral chloride conductance regulator (EBCR) and rat canalicular multispecific organic anion transporter (Cmoat) are found to be homologues based on protein sequence comparison and Northern blot analysis. EBCRis, therefore, renamed as rabbit Cmoat. The gene encoding CMOAT, a transporter possibly involved in Dubin-Johnson syndrome in humans, is mapped on human chromosome 10q24 and mouse chromosome 19D2.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

ATP-Binding Cassette Transporters / genetics
Animals
Anion Transport Proteins
Carrier Proteins / genetics*
Chromosome Mapping
Chromosomes, Human, Pair 10 / genetics*
Chromosomes, Human, Pair 10 / ultrastructure
Humans
In Situ Hybridization, Fluorescence
Ion Transport / genetics
Jaundice, Chronic Idiopathic / genetics
Mice / genetics*
Molecular Sequence Data
Rabbits
Rats
Species Specificity

Substances

ATP-Binding Cassette Transporters
Anion Transport Proteins
Carrier Proteins
mrp2 protein, Oryctolagus cuniculus

Associated data

GENBANK/U49248