Abstract
Within the past year, Armadillo and beta-catenin's role in transducing the Wingless/Wnt signal has been substantially clarified. It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. These partners not only play key roles in a variety of cell fate decisions during normal development but, when inappropriately activated, contribute to both colon cancer and melanoma.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Armadillo Domain Proteins
-
Cell Adhesion
-
Cell Movement
-
Cytoskeletal Proteins / metabolism
-
DNA-Binding Proteins / metabolism*
-
Drosophila / genetics
-
Drosophila / growth & development
-
Drosophila Proteins*
-
Gene Expression Regulation, Developmental
-
Insect Proteins / metabolism*
-
Lymphoid Enhancer-Binding Factor 1
-
Protein Binding
-
Signal Transduction
-
Trans-Activators*
-
Transcription Factors / metabolism*
-
beta Catenin
Substances
-
ARM protein, Drosophila
-
Armadillo Domain Proteins
-
Cytoskeletal Proteins
-
DNA-Binding Proteins
-
Drosophila Proteins
-
Insect Proteins
-
Lymphoid Enhancer-Binding Factor 1
-
Trans-Activators
-
Transcription Factors
-
beta Catenin