Abstract
Although previous analyses indicate that neocortical neurons originate from the cortical proliferative zone, evidence suggests that a subpopulation of neocortical interneurons originates within the subcortical telencephalon. For example, gamma-aminobutyric acid (GABA)-expressing cells migrate in vitro from the subcortical telencephalon into the neocortex. The number of GABA-expressing cells in neocortical slices is reduced by separating the neocortex from the subcortical telencephalon. Finally, mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Calbindins
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Cell Movement
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Corpus Striatum / cytology*
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Corpus Striatum / embryology
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Corpus Striatum / metabolism
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Culture Techniques
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Cytoskeletal Proteins
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / physiology
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Genes, Homeobox*
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Glutamate Decarboxylase / metabolism
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Homeodomain Proteins / genetics*
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Homeodomain Proteins / physiology
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Interneurons / chemistry
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Interneurons / physiology*
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Mice
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Mutation
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Neocortex / cytology*
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Neocortex / embryology
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Neocortex / metabolism
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RNA-Binding Proteins
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S100 Calcium Binding Protein G / analysis
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Telencephalon / cytology*
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Telencephalon / embryology
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Telencephalon / metabolism
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Transcription Factors
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gamma-Aminobutyric Acid / analysis
Substances
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Calbindins
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Cytoskeletal Proteins
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DNA-Binding Proteins
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Distal-less homeobox proteins
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Homeodomain Proteins
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RNA-Binding Proteins
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S100 Calcium Binding Protein G
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Tes protein, mouse
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Transcription Factors
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gamma-Aminobutyric Acid
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Glutamate Decarboxylase