Abstract
Although much is understood about the induction of genes expressed early (within 24 h) after T-cell activation, little is known about the regulation of expression of genes expressed 'late' (three or more days) post-stimulation. A better understanding of transcriptional regulation at this important stage of T-cell maturation may yield new insights into T-cell development and new immunotherapeutic targets.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Differentiation
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Chemokine CCL5 / genetics*
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Humans
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Immunotherapy
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Lymphocyte Activation / genetics
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Promoter Regions, Genetic
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
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Time Factors
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Transcription Factors / metabolism
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Transcription, Genetic
Substances
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Chemokine CCL5
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Transcription Factors