Molecular features of colchicine associated with antimitotic activity and inhibition of tubulin polymerization

Biochem Pharmacol. 1976 Jun 15;25(12):1383-7. doi: 10.1016/0006-2952(76)90108-8.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Chemistry / drug effects
  • Chemical Phenomena
  • Chemistry
  • Colchicine / analogs & derivatives
  • Colchicine / pharmacology*
  • Depression, Chemical
  • Female
  • Glycoproteins / metabolism*
  • HeLa Cells
  • Humans
  • In Vitro Techniques
  • Mice
  • Mitosis / drug effects*
  • Structure-Activity Relationship
  • Tropanes / pharmacology
  • Tubulin / metabolism*
  • Viscosity

Substances

  • Glycoproteins
  • Tropanes
  • Tubulin
  • Colchicine