A new locus for non-syndromal, autosomal recessive, sensorineural hearing loss (DFNB16) maps to human chromosome 15q21-q22

D A Campbell; D P McHale; K A Brown; L M Moynihan; M Houseman; G Karbani; G Parry; A H Janjua; V Newton; L al-Gazali; A F Markham; N J Lench; R F Mueller

doi:10.1136/jmg.34.12.1015

A new locus for non-syndromal, autosomal recessive, sensorineural hearing loss (DFNB16) maps to human chromosome 15q21-q22

J Med Genet. 1997 Dec;34(12):1015-7. doi: 10.1136/jmg.34.12.1015.

Authors

D A Campbell¹, D P McHale, K A Brown, L M Moynihan, M Houseman, G Karbani, G Parry, A H Janjua, V Newton, L al-Gazali, A F Markham, N J Lench, R F Mueller

Affiliation

¹ Molecular Medicine Unit, St James's University Hospital, Leeds, UK.

Abstract

Non-syndromal, recessive deafness (NSRD) is the most common form of inherited deafness or hearing impairment in humans. NSRD is genetically heterogeneous and it has been estimated that as many as 35 different loci may be involved. We report the mapping of a novel locus for autosomal recessive, non-syndromal deafness (DFNB16) in three consanguineous families originating from Pakistan and the Middle East. Using multipoint analysis (HOMOZ/MAPMAKER) a maximum combined lod score of 6.5 was obtained for the interval D15S1039-D15S123. Recombination events and haplotype analysis define a 12-14 cM critical region between the markers D15S1039 and D15S155 on chromosome 15q15-q21.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping*
Chromosomes, Human, Pair 15*
Deafness / genetics*
Female
Genes, Recessive
Humans
Male

Grants and funding

Wellcome Trust/United Kingdom