Abstract
CD137 (ILA/4-1BB), a member of the TNF receptor family, was shown previously to inhibit proliferation and to induce apoptosis in T lymphocytes. In this study, we identify CD137 as a novel and potent monocyte activation factor. CD137 protein induces expression of IL-6, IL-8, and TNF-alpha, and inhibits expression of IL-10. Furthermore, CD137 differentially regulates expression of cell surface receptors. It induces expression of ICAM and reduces expression of FcgammaRIII, while levels of HLA-DR remain unchanged. CD137 also promotes adherence of monocytes. These effects of CD137 require immobilization of CD137 protein, indicating that they are mediated by cross-linking of a corresponding ligand/coreceptor expressed on monocytes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, CD
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Binding, Competitive / immunology
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Cell Adhesion / drug effects
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Cell Adhesion / immunology
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Cells, Cultured
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Down-Regulation / immunology
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Gene Expression Regulation
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Humans
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Interleukin-6 / biosynthesis
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Interleukin-8 / biosynthesis
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Interleukin-8 / genetics
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Monocytes / drug effects
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Monocytes / immunology*
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Monocytes / metabolism
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Polymerase Chain Reaction / methods
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Receptors, IgG / antagonists & inhibitors
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Receptors, IgG / biosynthesis
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Receptors, Nerve Growth Factor / immunology
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Receptors, Nerve Growth Factor / metabolism
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Receptors, Nerve Growth Factor / physiology*
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Receptors, Tumor Necrosis Factor / immunology
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Receptors, Tumor Necrosis Factor / metabolism
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Receptors, Tumor Necrosis Factor / physiology*
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Signal Transduction / drug effects
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Signal Transduction / immunology*
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Tumor Necrosis Factor Receptor Superfamily, Member 9
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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Antigens, CD
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Interleukin-6
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Interleukin-8
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Receptors, IgG
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Receptors, Nerve Growth Factor
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Receptors, Tumor Necrosis Factor
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TNFRSF9 protein, human
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Tumor Necrosis Factor Receptor Superfamily, Member 9
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Tumor Necrosis Factor-alpha