Abstract
Epstein-Barr virus (EBV) is strongly associated with nasopharyngeal carcinoma and some lymphoepithelioma-like carcinomas from other anatomic sites. This study investigates the presence of EBV in breast cancer. Immunohistochemistry for EBV proteins (EBV nuclear antigen-2 and latent membrane protein-1) and in situ hybridization for EBV-encoded small nuclear RNAs (EBER-1 and -2) were performed in 60 invasive breast cancers. None of the 60 breast cancer samples showed detectable EBV. These results suggest that EBV may not play a significant role in the etiology of breast cancers in Taiwan.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Breast Neoplasms / chemistry
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Breast Neoplasms / virology*
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Epstein-Barr Virus Nuclear Antigens / analysis*
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Female
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Herpesviridae Infections / metabolism*
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Herpesviridae Infections / virology
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Herpesvirus 4, Human*
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Humans
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Immunohistochemistry
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In Situ Hybridization
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Middle Aged
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RNA, Small Nuclear / analysis
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RNA, Viral / analysis
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Tumor Virus Infections / metabolism*
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Tumor Virus Infections / virology
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Viral Matrix Proteins / analysis*
Substances
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EBV-associated membrane antigen, Epstein-Barr virus
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Epstein-Barr Virus Nuclear Antigens
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RNA, Small Nuclear
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RNA, Viral
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Viral Matrix Proteins