Abstract
Expression cloning revealed a chloride channel (ICln) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human ICln-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Chloride Channels / biosynthesis
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Chloride Channels / chemistry
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Chloride Channels / genetics*
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Chromosome Mapping
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Chromosomes, Human, Pair 11*
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Chromosomes, Human, Pair 6*
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DNA Primers
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Exons
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Genomic Library
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Humans
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In Situ Hybridization, Fluorescence
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Introns
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Ion Channels*
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Molecular Sequence Data
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Open Reading Frames
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Polymerase Chain Reaction
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Sequence Alignment
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Sequence Homology, Amino Acid
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Sequence Homology, Nucleic Acid
Substances
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CLNS1A protein, human
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Chloride Channels
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DNA Primers
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Ion Channels