Abstract
We investigated the capacity of intramuscular (i.m.) immunization with heterologous-host rotavirus (simian strain RRV) to induce mucosal virus-specific memory B cells in mice. We found that prior i.m. immunization enhanced the magnitude of mucosal virus-specific immunoglobulin A (IgA) production but did not alter the site and timing of induction of virus-specific IgA responses after challenge.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Viral / biosynthesis
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B-Lymphocytes / immunology*
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Female
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Haplorhini
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Immunity, Mucosal / immunology
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Immunoglobulin A / biosynthesis
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Immunologic Memory / immunology*
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Injections, Intramuscular
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Intestinal Mucosa / cytology
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Intestinal Mucosa / immunology*
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Mice
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Mice, Inbred BALB C
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Rotavirus / immunology*
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Rotavirus Infections / immunology
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Rotavirus Infections / prevention & control*
Substances
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Antibodies, Viral
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Immunoglobulin A