Abstract
TRAIL/Apo-2L induces rapid apoptosis of a variety of tumor cell lines. A family of tumor necrosis factor receptor-related molecules have been identified as receptors for TRAIL. Herein, we report the identification of another member of the TRAIL receptor family, TRUNDD (TRAIL receptor with a truncated death domain). The TRUNDD transcript was detected in multiple human tissues. TRUNDD is highly homologous to all known TRAIL receptors and has an extracellular TRAIL-binding domain but lacks a functional intracellular death domain and does not induce apoptosis. Consistent with an inhibitory role, ectopic expression of TRUNDD attenuated TRAIL-induced apoptosis in mammalian cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Apoptosis
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Apoptosis Regulatory Proteins
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Cells, Cultured
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Humans
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Membrane Glycoproteins / antagonists & inhibitors*
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Membrane Glycoproteins / metabolism
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Membrane Proteins*
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Molecular Sequence Data
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Receptors, Tumor Necrosis Factor / genetics*
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Receptors, Tumor Necrosis Factor / isolation & purification
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Sequence Alignment
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Sequence Homology, Amino Acid
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TNF-Related Apoptosis-Inducing Ligand
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Tissue Distribution
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Tumor Necrosis Factor Decoy Receptors
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Apoptosis Regulatory Proteins
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Membrane Glycoproteins
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Membrane Proteins
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Receptors, Tumor Necrosis Factor
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TNF-Related Apoptosis-Inducing Ligand
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TNFRSF10D protein, human
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TNFSF10 protein, human
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Tumor Necrosis Factor Decoy Receptors
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Tumor Necrosis Factor-alpha