Two 7 alpha-hydroxylase enzymes in bile acid biosynthesis

Curr Opin Lipidol. 1998 Apr;9(2):113-8. doi: 10.1097/00041433-199804000-00006.

Abstract

The addition of a 7-hydroxyl group is an early and often rate-limiting step in the synthesis of bile acids. This reaction is catalysed by two cytochrome P450 enzymes known as cholesterol 7 alpha-hydroxylase and oxysterol 7 alpha-hydroxylase. cDNAs encoding these proteins have been isolated and used to define two evolutionarily conserved pathways that produce 7 alpha-hydroxylated bile acids.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Aryl Hydrocarbon Hydroxylases*
  • Bile Acids and Salts / biosynthesis*
  • Cytochrome P-450 Enzyme System / chemistry
  • Cytochrome P-450 Enzyme System / metabolism*
  • Cytochrome P450 Family 7
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Mice
  • Molecular Sequence Data
  • Mutagenesis
  • Sequence Homology, Amino Acid
  • Steroid Hydroxylases / chemistry
  • Steroid Hydroxylases / metabolism*

Substances

  • Bile Acids and Salts
  • Cytochrome P-450 Enzyme System
  • Steroid Hydroxylases
  • oxysterol 7-alpha-hydroxylase
  • Aryl Hydrocarbon Hydroxylases
  • steroid hormone 7-alpha-hydroxylase
  • Cytochrome P450 Family 7
  • CYP7B1 protein, human