Abstract
The addition of a 7-hydroxyl group is an early and often rate-limiting step in the synthesis of bile acids. This reaction is catalysed by two cytochrome P450 enzymes known as cholesterol 7 alpha-hydroxylase and oxysterol 7 alpha-hydroxylase. cDNAs encoding these proteins have been isolated and used to define two evolutionarily conserved pathways that produce 7 alpha-hydroxylated bile acids.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Aryl Hydrocarbon Hydroxylases*
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Bile Acids and Salts / biosynthesis*
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Cytochrome P-450 Enzyme System / chemistry
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Cytochrome P-450 Enzyme System / metabolism*
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Cytochrome P450 Family 7
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Gene Expression Regulation, Enzymologic
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Humans
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Mice
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Molecular Sequence Data
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Mutagenesis
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Sequence Homology, Amino Acid
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Steroid Hydroxylases / chemistry
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Steroid Hydroxylases / metabolism*
Substances
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Bile Acids and Salts
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Cytochrome P-450 Enzyme System
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Steroid Hydroxylases
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oxysterol 7-alpha-hydroxylase
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Aryl Hydrocarbon Hydroxylases
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steroid hormone 7-alpha-hydroxylase
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Cytochrome P450 Family 7
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CYP7B1 protein, human