Indomethacin for prevention of heterotopic ossification after hip arthroplasty. A randomized comparison between 4 and 8 days of treatment

U Dorn; C Grethen; H Effenberger; H Berka; T Ramsauer; T Drekonja

doi:10.3109/17453679809117607

Indomethacin for prevention of heterotopic ossification after hip arthroplasty. A randomized comparison between 4 and 8 days of treatment

Acta Orthop Scand. 1998 Apr;69(2):107-10. doi: 10.3109/17453679809117607.

Authors

U Dorn¹, C Grethen, H Effenberger, H Berka, T Ramsauer, T Drekonja

Affiliation

¹ Orthopedic Department, Salzburg General Hospital, Austria.

PMID: 9602763
DOI: 10.3109/17453679809117607

Abstract

In a randomized, parallel group study, we evaluated the efficacy of a 4-day versus an 8-day course of indomethacin (50 mg, 3 times per day), given as prophylaxis against heterotopic ossification after cementless total hip arthroplasty in 209 patients with arthrosis. Patients receiving the prophylaxis for 8 days had less (p = 0.03) severe heterotopic bone formation.

Publication types

Clinical Trial
Comparative Study
Randomized Controlled Trial

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Arthroplasty, Replacement, Hip / adverse effects*
Female
Humans
Indomethacin / administration & dosage*
Indomethacin / therapeutic use
Male
Ossification, Heterotopic / etiology
Ossification, Heterotopic / prevention & control*
Osteoarthritis, Hip / surgery
Prospective Studies
Time Factors
Treatment Outcome

Substances

Anti-Inflammatory Agents, Non-Steroidal
Indomethacin