Abstract
The nucleotide sequences containing the rat interleukin-12 p40 gene was determined. Sequencing revealed the presence of six exons and five introns. Analysis of the 5' non-coding region showed the presence of several possible sites involved in cytokine gene regulation at the transcriptional level. Comparison of the deduced amino acid sequence of rat IL-12 p40 with that of the mouse and of human p40, showed 92% and 65% identity respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Binding Sites / genetics
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Cloning, Molecular
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DNA, Complementary / chemistry
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DNA, Complementary / genetics
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Exons / genetics
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Gene Expression Regulation
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Genes / genetics*
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Interleukin-12 / chemistry
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Interleukin-12 / genetics*
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Introns / genetics
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Molecular Sequence Data
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Rats
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Sequence Alignment
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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Transcription, Genetic / genetics
Substances
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DNA, Complementary
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Interleukin-12