Abstract
Current models suggest that continuous antigenic stimulation of memory B cells is required to maintain long-term antibody production. In view of recent developments concerning plasma cell longevity, a new model is described that incorporates the important role of long-lived plasma cells in sustaining persistent antibody responses.
MeSH terms
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Animals
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Antibody Formation*
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Antigen-Antibody Complex / immunology
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B-Lymphocyte Subsets / immunology
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Cell Movement
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Cellular Senescence
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Chronic Disease
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Cross Reactions
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Dendritic Cells / immunology
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Humans
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Immunoglobulin Idiotypes / immunology
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Immunologic Memory / immunology*
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Lymphocyte Activation
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Mice
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Models, Immunological
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Plasma Cells / cytology*
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Plasma Cells / immunology
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Vaccination
Substances
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Antigen-Antibody Complex
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Immunoglobulin Idiotypes