Negative regulation of T cell activation

Curr Opin Immunol. 1998 Jun;10(3):313-21. doi: 10.1016/s0952-7915(98)80170-2.

Abstract

T cell activation is negatively regulated by cytotoxic T lymphocyte antigen 4 (CTLA-4) and the killer cell inhibitory receptors. Endocytosis and signaling of CTLA-4 are regulated by tyrosine phosphorylation. While T cell activation is mediated by phosphorylation of immunoreceptor tyrosine-based activation motifs and tyrosine kinases, inhibitory signals are delivered by tyrosine phosphatases. Unresponsiveness is also induced by modulation of signaling components of the T cell receptor complex.

Publication types

  • Review

MeSH terms

  • Abatacept
  • Animals
  • Antigens, CD
  • Antigens, Differentiation / genetics
  • Antigens, Differentiation / physiology*
  • CTLA-4 Antigen
  • Consensus Sequence
  • Cytokines / physiology
  • Endocytosis
  • Gene Expression Regulation
  • Gene Rearrangement, T-Lymphocyte
  • Humans
  • Immunoconjugates*
  • Killer Cells, Natural / immunology
  • Lymphocyte Activation / drug effects
  • Lymphocyte Activation / physiology*
  • Lysosomes / physiology
  • Models, Immunological
  • Oxidation-Reduction
  • Phosphorylation
  • Protein Processing, Post-Translational
  • Protein Tyrosine Phosphatases / physiology
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Cytokine / physiology
  • Receptors, Immunologic / physiology
  • Receptors, KIR
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • Cytokines
  • Immunoconjugates
  • Receptors, Antigen, T-Cell
  • Receptors, Cytokine
  • Receptors, Immunologic
  • Receptors, KIR
  • Abatacept
  • Protein Tyrosine Phosphatases