Abstract
1. 2-Oxoglutarate, succinate, fumarate, malate and citrate, cis-aconitate and isocitrate stimulate conversion of cholesterol to progesterone in human placental mitochondria. 2. The stimulatory effect of dicarboxylic and tricarboxylic acids depends on the activity of malate dehydrogenase (decarboxylating) (NADP+) (EC 1.1.1.40) and isocitrate dehydrogenase (NADP+) (EC 1.1.1.42), respectively.
MeSH terms
-
Aconitic Acid / pharmacology
-
Citrates / pharmacology
-
Citric Acid Cycle*
-
Drug Synergism
-
Female
-
Fumarates / pharmacology
-
Humans
-
Isocitrate Dehydrogenase / metabolism
-
Isocitrates / pharmacology
-
Ketoglutaric Acids / pharmacology
-
Malate Dehydrogenase / metabolism
-
Malates / pharmacology
-
Malonates / pharmacology
-
Manganese / pharmacology
-
Mitochondria / drug effects
-
Mitochondria / metabolism*
-
Placenta / metabolism*
-
Pregnancy
-
Progesterone / biosynthesis*
-
Succinates / pharmacology
Substances
-
Citrates
-
Fumarates
-
Isocitrates
-
Ketoglutaric Acids
-
Malates
-
Malonates
-
Succinates
-
Manganese
-
Progesterone
-
Aconitic Acid
-
Malate Dehydrogenase
-
Isocitrate Dehydrogenase