Abstract
The field of antisense therapeutics has attracted great interest during the past decade. A large body of literature has recently appeared in which the antisense mechanism is claimed to be involved and a number of human clinical trials are underway. Questions regarding the specificity of action and side effects of antisense phosphorothioate oligonucleotides have arisen simultaneously.
MeSH terms
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Animals
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Antineoplastic Agents / therapeutic use
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Antiviral Agents / therapeutic use
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Drug Design
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Drug Therapy, Combination
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Humans
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Oligonucleotides, Antisense / pharmacokinetics
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Oligonucleotides, Antisense / therapeutic use*
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Oligonucleotides, Antisense / toxicity
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Thionucleotides / pharmacokinetics
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Thionucleotides / therapeutic use*
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Thionucleotides / toxicity
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Tissue Distribution
Substances
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Antineoplastic Agents
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Antiviral Agents
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Oligonucleotides, Antisense
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Thionucleotides