Abstract
The activation of caspases is a final commitment step for apoptosis. It is now evident that signal transduction pathways involving specific protein kinases modulate the apoptotic response. Both pro-apoptotic and anti-apoptotic pathways integrate environmental cues that control the decision to undergo apoptosis. Pro- and anti-apoptotic signal pathways regulate the activation of the caspases. In this review we describe our current understanding of apoptotic signal transduction.
MeSH terms
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Animals
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Apoptosis / physiology*
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Caspases / metabolism
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Cytokines / metabolism
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Growth Substances / metabolism
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Humans
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MAP Kinase Kinase 3
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Mitogen-Activated Protein Kinase Kinases*
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Phosphatidylinositol 3-Kinases / metabolism
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Protein Serine-Threonine Kinases / metabolism
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Protein-Tyrosine Kinases / metabolism
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Proto-Oncogene Proteins c-bcl-2 / genetics
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Signal Transduction*
Substances
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Cytokines
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Growth Substances
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Proto-Oncogene Proteins c-bcl-2
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Protein-Tyrosine Kinases
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Protein Serine-Threonine Kinases
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MAP Kinase Kinase 3
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MAP2K3 protein, human
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Mitogen-Activated Protein Kinase Kinases
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Caspases