Abstract
Accelerator Mass Spectrometry is a mass spectrometric method of detecting long-lived radioisotopes without regard to their decay products or half-life. The technique is normally applied to geochronology, but is also available for bioanalytical tracing. AMS detects isotope concentrations to parts per quadrillion, quantifying labeled biochemicals to attomole levels in milligram-sized samples. Its advantages over non-isotopic and stable isotope labeling methods are reviewed and examples of analytical integrity, sensitivity, specificity, and applicability are provided.
Publication types
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Review
MeSH terms
-
Animals
-
Calcium Isotopes / analysis
-
Carbon Isotopes / analysis
-
Carcinogens / analysis
-
Chemistry Techniques, Analytical / instrumentation*
-
Chromatography, High Pressure Liquid
-
Deuterium / analysis
-
Gas Chromatography-Mass Spectrometry*
-
Humans
-
Models, Biological*
-
Nutritional Physiological Phenomena*
-
Particle Accelerators*
-
Quinolines / urine
-
Radioactive Tracers*
-
Rats
-
Sensitivity and Specificity
Substances
-
Calcium Isotopes
-
Carbon Isotopes
-
Carcinogens
-
Quinolines
-
Radioactive Tracers
-
Deuterium
-
2-amino-3,4-dimethylimidazo(4,5-f)quinoline