Abstract
Toward a genetic dissection of the processes involved in aging, a screen for gene mutations that extend life-span in Drosophila melanogaster was performed. The mutant line methuselah (mth) displayed approximately 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator. The mth gene predicted a protein with homology to several guanosine triphosphate-binding protein-coupled seven-transmembrane domain receptors. Thus, the organism may use signal transduction pathways to modulate stress response and life-span.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Animals, Genetically Modified
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Base Sequence
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Cloning, Molecular
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DNA Transposable Elements
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Drosophila Proteins*
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Drosophila melanogaster / genetics*
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Drosophila melanogaster / physiology*
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Female
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Food Deprivation
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GTP-Binding Proteins / chemistry
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GTP-Binding Proteins / genetics*
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GTP-Binding Proteins / metabolism
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GTP-Binding Proteins / physiology
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Genes, Insect*
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Hot Temperature
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Insecticide Resistance
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Longevity / genetics
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Male
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Molecular Sequence Data
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Mutation
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Oxidative Stress
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Paraquat / pharmacology
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Receptors, Cell Surface / chemistry
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Receptors, Cell Surface / genetics*
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Receptors, Cell Surface / metabolism
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Receptors, Cell Surface / physiology
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Receptors, G-Protein-Coupled*
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Signal Transduction
Substances
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DNA Transposable Elements
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Drosophila Proteins
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Receptors, Cell Surface
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Receptors, G-Protein-Coupled
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mth protein, Drosophila
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GTP-Binding Proteins
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Paraquat