Abstract
Homeobox gene expression was examined in the erythroleukaemic cell line TF-1. Expression of a number of HOX A, B and C genes, including HOX A7 was detected. Expression of this gene has not previously been reported in erythroleukaemic cell lines. A 2.1 kb full length cDNA of the HOX A7 gene was cloned. The predicted amino acid sequence C-terminal to the homeodomain consists of an alanine-rich region and a strongly negatively charged domain consisting entirely of aspartic and glutamic acid residues.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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DNA, Complementary
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Erythropoietin / pharmacology
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Gene Expression Regulation, Neoplastic / drug effects
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Genes, Homeobox*
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Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
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Homeodomain Proteins / biosynthesis
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Homeodomain Proteins / chemistry
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Homeodomain Proteins / genetics*
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Humans
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Leukemia, Erythroblastic, Acute
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Molecular Sequence Data
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Neoplasm Proteins*
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Polymerase Chain Reaction
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Tumor Cells, Cultured
Substances
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DNA, Complementary
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HOXA7 protein, human
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Homeodomain Proteins
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Neoplasm Proteins
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Erythropoietin
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Granulocyte-Macrophage Colony-Stimulating Factor