Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1

Biochim Biophys Acta. 1998 Nov 8;1442(2-3):329-33. doi: 10.1016/s0167-4781(98)00170-5.

Abstract

Homeobox gene expression was examined in the erythroleukaemic cell line TF-1. Expression of a number of HOX A, B and C genes, including HOX A7 was detected. Expression of this gene has not previously been reported in erythroleukaemic cell lines. A 2.1 kb full length cDNA of the HOX A7 gene was cloned. The predicted amino acid sequence C-terminal to the homeodomain consists of an alanine-rich region and a strongly negatively charged domain consisting entirely of aspartic and glutamic acid residues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • DNA, Complementary
  • Erythropoietin / pharmacology
  • Gene Expression Regulation, Neoplastic / drug effects
  • Genes, Homeobox*
  • Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
  • Homeodomain Proteins / biosynthesis
  • Homeodomain Proteins / chemistry
  • Homeodomain Proteins / genetics*
  • Humans
  • Leukemia, Erythroblastic, Acute
  • Molecular Sequence Data
  • Neoplasm Proteins*
  • Polymerase Chain Reaction
  • Tumor Cells, Cultured

Substances

  • DNA, Complementary
  • HOXA7 protein, human
  • Homeodomain Proteins
  • Neoplasm Proteins
  • Erythropoietin
  • Granulocyte-Macrophage Colony-Stimulating Factor

Associated data

  • GENBANK/AJ005814