Protein tyrosine phosphatases: mechanisms of catalysis and regulation

Curr Opin Chem Biol. 1998 Oct;2(5):633-41. doi: 10.1016/s1367-5931(98)80095-1.

Abstract

Recent structural information suggests that the HC(X)5R active-site motif defines three distinct evolutionary families of phosphatases that employ a common catalytic mechanism. In two instances, regulation of phosphatase activity employs autoinhibitory mechanisms involving either intermolecular or intramolecular interactions, whereby inhibition is mediated by sterically blocking the active-site cleft.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Binding Sites / physiology*
  • Biological Evolution*
  • Catalytic Domain / physiology*
  • Cell Cycle Proteins / chemistry
  • Cell Cycle Proteins / metabolism
  • Crystallography, X-Ray
  • Dual Specificity Phosphatase 1
  • Immediate-Early Proteins / chemistry
  • Immediate-Early Proteins / metabolism
  • Intracellular Signaling Peptides and Proteins
  • Phosphoprotein Phosphatases*
  • Protein Phosphatase 1
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • Protein Tyrosine Phosphatases / chemistry
  • Protein Tyrosine Phosphatases / metabolism*
  • Receptor-Like Protein Tyrosine Phosphatases, Class 4
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / metabolism
  • SH2 Domain-Containing Protein Tyrosine Phosphatases
  • Thiosulfate Sulfurtransferase / chemistry
  • Thiosulfate Sulfurtransferase / metabolism
  • src Homology Domains / physiology

Substances

  • Cell Cycle Proteins
  • Immediate-Early Proteins
  • Intracellular Signaling Peptides and Proteins
  • Receptors, Cell Surface
  • Thiosulfate Sulfurtransferase
  • Phosphoprotein Phosphatases
  • Protein Phosphatase 1
  • Dual Specificity Phosphatase 1
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • Protein Tyrosine Phosphatases
  • Receptor-Like Protein Tyrosine Phosphatases, Class 4
  • SH2 Domain-Containing Protein Tyrosine Phosphatases