Abstract
Inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice was observed in the methanol extract of rice bran and gamma-oryzanol. The active components of rice bran, sitosterol ferulate, 24-methylcholesterol ferulate, cycloartenol ferulate and 24-methylenecycloartanol ferulate inhibited markedly the TPA-induced inflammation in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 0.2-0.3 mg/ear. Furthermore, cycloartenol ferulate markedly inhibited the tumor-promoting effect of TPA in 7,12-dimethylbenz[a]anthracene-initiated mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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9,10-Dimethyl-1,2-benzanthracene
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Animals
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Anticarcinogenic Agents / therapeutic use*
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Carcinogens
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Cocarcinogenesis*
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Dermatitis, Contact / etiology
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Dermatitis, Contact / prevention & control
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Female
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Hypolipidemic Agents / therapeutic use
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Mice
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Mice, Inbred ICR
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Oryza / chemistry*
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Phenylpropionates / therapeutic use
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Phytosterols / therapeutic use*
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Plant Extracts / therapeutic use*
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Skin / drug effects
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Skin Neoplasms / chemically induced*
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Skin Neoplasms / prevention & control*
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Sterols / therapeutic use
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Tetradecanoylphorbol Acetate
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Triterpenes
Substances
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Anticarcinogenic Agents
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Carcinogens
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Hypolipidemic Agents
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Phenylpropionates
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Phytosterols
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Plant Extracts
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Sterols
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Triterpenes
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9,10-Dimethyl-1,2-benzanthracene
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Tetradecanoylphorbol Acetate
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gamma-oryzanol
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cycloartenol