Abstract
A new highly oxygenated triterpene named ganoderic acid alpha has been isolated from a methanol extract of the fruiting bodies of Ganoderma lucidum together with twelve known compounds. The structures of the isolated compounds were determined by spectroscopic means including 2D-NMR. Ganoderiol F and ganodermanontriol were found to be active as anti-HIV-1 agents with an inhibitory concentration of 7.8 micrograms ml-1 for both, and ganoderic acid B, ganoderiol B, ganoderic acid C1, 3 beta-5 alpha-dihydroxy-6 beta-methoxyergosta-7,22-diene, ganoderic acid alpha, ganoderic acid H and ganoderiol A were moderately active inhibitors against HIV-1 PR with a 50% inhibitory concentration of 0.17-0.23 mM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology
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Cell Line
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Cytopathogenic Effect, Viral / drug effects
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Drugs, Chinese Herbal / pharmacology*
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HIV Protease Inhibitors / chemistry
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HIV Protease Inhibitors / isolation & purification*
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HIV Protease Inhibitors / pharmacology
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HIV-1 / drug effects
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HIV-1 / pathogenicity
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Medicine, Chinese Traditional
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Plants, Medicinal / chemistry*
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Reverse Transcriptase Inhibitors / chemistry
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Reverse Transcriptase Inhibitors / isolation & purification
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Reverse Transcriptase Inhibitors / pharmacology
Substances
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Anti-HIV Agents
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Drugs, Chinese Herbal
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HIV Protease Inhibitors
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Reverse Transcriptase Inhibitors