Lysophosphatidylcholine generates superoxide anions through activation of phosphatidylinositol 3-kinase in human neutrophils

FEBS Lett. 1998 Dec 11;441(1):63-6. doi: 10.1016/s0014-5793(98)01526-9.

Abstract

Lysophosphatidylcholine (LPC) accumulates in inflammatory tissues, where neutrophils are recruited to generate superoxide anions (O2.-). Here, we show that LPC stimulates O2.- generation in human neutrophils and that the activity is inhibited with phosphatidylinositol 3-kinase (PI3 kinase) inhibitors, but not with protein kinase C (PKC) inhibitors. Furthermore, we demonstrate that LPC activates PI3 kinase in neutrophils. Thus, LPC might contribute to host defense by generating O2.- in neutrophils through PI3 kinase activation, but not through PKC activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Androstadienes / pharmacology
  • Cell Survival
  • Enzyme Activation
  • Enzyme Inhibitors / pharmacology
  • Humans
  • In Vitro Techniques
  • Kinetics
  • Lysophosphatidylcholines / pharmacology*
  • N-Formylmethionine Leucyl-Phenylalanine / pharmacology
  • Neutrophils / cytology
  • Neutrophils / drug effects
  • Neutrophils / physiology*
  • Phosphatidylinositol 3-Kinases / blood*
  • Phosphoinositide-3 Kinase Inhibitors
  • Protein Kinase C / antagonists & inhibitors
  • Protein Kinase C / blood
  • Superoxides / blood*
  • Tetradecanoylphorbol Acetate / pharmacology
  • Wortmannin

Substances

  • Androstadienes
  • Enzyme Inhibitors
  • Lysophosphatidylcholines
  • Phosphoinositide-3 Kinase Inhibitors
  • Superoxides
  • N-Formylmethionine Leucyl-Phenylalanine
  • Protein Kinase C
  • Tetradecanoylphorbol Acetate
  • Wortmannin