Abstract
Alminoprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. It has anti-inflammatory properties different from the classical NSAID. Using both in vitro systems of cells in culture and in vivo models of inflammation, we report here that alminoprofen possesses both antiphospholipase A2 (PLA2) activity and anti-cycloxygenase (COX) activity. The PLA2 targeted by alminoprofen is likely the secretory phospholipase A2 (sPLA2) while the COX targeted is the COX-2.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Cell Line
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Cyclooxygenase 1
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Cyclooxygenase 2
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors / pharmacology
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Dinoprostone / analysis
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Edema / chemically induced
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Edema / drug therapy
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Flurbiprofen / pharmacology
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Group II Phospholipases A2
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Humans
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Indans / pharmacology
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Indomethacin / pharmacology
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Isoenzymes / metabolism
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Melitten
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Membrane Proteins
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Phospholipases A / antagonists & inhibitors*
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Phospholipases A / toxicity
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Phospholipases A2
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Phospholipids / metabolism*
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Propionates / pharmacology*
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Propionates / therapeutic use
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Prostaglandin-Endoperoxide Synthases / metabolism
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Prostaglandins F / analysis
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Rats
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Rats, Wistar
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors
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Indans
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Isoenzymes
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L 745337
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Membrane Proteins
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Phospholipids
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Propionates
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Prostaglandins F
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alminoprofen
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Melitten
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Flurbiprofen
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Cyclooxygenase 1
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Cyclooxygenase 2
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PTGS1 protein, human
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PTGS2 protein, human
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Prostaglandin-Endoperoxide Synthases
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Ptgs1 protein, rat
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Phospholipases A
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Group II Phospholipases A2
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Phospholipases A2
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Dinoprostone
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prostaglandin F1
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Indomethacin