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Page 1
The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia.
Haematologica. 2019 May;104(5):963-972. doi: 10.3324/haematol.2018.195172. Epub 2018 Dec 20.
Haematologica. 2019.
PMID: 30573504
Free PMC article.
AML refractory to primary induction with Ida-FLAG has a poor clinical outcome.
Kavanagh S, Heath E, Hurren R, Gronda M, Barghout SH, Liyanage SU, Siriwardena TP, Claudio J, Zhang T, Sukhai M, Stockley TL, Kamel-Reid S, Rostom A, Lutynski A, Khalaf D, Rydlewski A, Chan SM, Gupta V, Maze D, Sibai H, Schuh AC, Yee K, Minden MD, Schimmer AD.
Kavanagh S, et al. Among authors: liyanage su.
Leuk Res. 2018 May;68:22-28. doi: 10.1016/j.leukres.2018.02.012. Epub 2018 Feb 20.
Leuk Res. 2018.
PMID: 29518628
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Targeting mitochondrial RNA polymerase in acute myeloid leukemia.
Bralha FN, Liyanage SU, Hurren R, Wang X, Son MH, Fung TA, Chingcuanco FB, Tung AY, Andreazza AC, Psarianos P, Schimmer AD, Salmena L, Laposa RR.
Bralha FN, et al. Among authors: liyanage su.
Oncotarget. 2015 Nov 10;6(35):37216-28. doi: 10.18632/oncotarget.6129.
Oncotarget. 2015.
PMID: 26484416
Free PMC article.
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Mitochondrial Targeting of Doxorubicin Eliminates Nuclear Effects Associated with Cardiotoxicity.
Jean SR, Tulumello DV, Riganti C, Liyanage SU, Schimmer AD, Kelley SO.
Jean SR, et al. Among authors: liyanage su.
ACS Chem Biol. 2015 Sep 18;10(9):2007-15. doi: 10.1021/acschembio.5b00268. Epub 2015 Jun 18.
ACS Chem Biol. 2015.
PMID: 26038829
Free article.
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Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML.
Liyanage SU, Hurren R, Voisin V, Bridon G, Wang X, Xu C, MacLean N, Siriwardena TP, Gronda M, Yehudai D, Sriskanthadevan S, Avizonis D, Shamas-Din A, Minden MD, Bader GD, Laposa R, Schimmer AD.
Liyanage SU, et al.
Blood. 2017 May 11;129(19):2657-2666. doi: 10.1182/blood-2016-10-741207. Epub 2017 Mar 10.
Blood. 2017.
PMID: 28283480
Free PMC article.
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Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria.
Liyanage SU, Coyaud E, Laurent EM, Hurren R, Maclean N, Wood SR, Kazak L, Shamas-Din A, Holt I, Raught B, Schimmer A.
Liyanage SU, et al.
Mitochondrion. 2017 Jan;32:31-35. doi: 10.1016/j.mito.2016.11.001. Epub 2016 Nov 11.
Mitochondrion. 2017.
PMID: 27845271
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