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Heme modulates Trypanosoma cruzi bioenergetics inducing mitochondrial ROS production.
Nogueira NP, Saraiva FMS, Oliveira MP, Mendonça APM, Inacio JDF, Almeida-Amaral EE, Menna-Barreto RF, Laranja GAT, Torres EJL, Oliveira MF, Paes MC. Nogueira NP, et al. Free Radic Biol Med. 2017 Jul;108:183-191. doi: 10.1016/j.freeradbiomed.2017.03.027. Epub 2017 Mar 29. Free Radic Biol Med. 2017. PMID: 28363600
Gene expression profiling of Trypanosoma cruzi in the presence of heme points to glycosomal metabolic adaptation of epimastigotes inside the vector.
Paes MC, Saraiva FMS, Nogueira NP, Vieira CSD, Dias FA, Rossini A, Coelho VL, Pane A, Sang F, Alcocer M. Paes MC, et al. Among authors: nogueira np. PLoS Negl Trop Dis. 2020 Jan 2;14(1):e0007945. doi: 10.1371/journal.pntd.0007945. eCollection 2020 Jan. PLoS Negl Trop Dis. 2020. PMID: 31895927 Free PMC article.