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The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.
Abdel-Nour M, Carneiro LAM, Downey J, Tsalikis J, Outlioua A, Prescott D, Da Costa LS, Hovingh ES, Farahvash A, Gaudet RG, Molinaro R, van Dalen R, Lau CCY, Azimi FC, Escalante NK, Trotman-Grant A, Lee JE, Gray-Owen SD, Divangahi M, Chen JJ, Philpott DJ, Arnoult D, Girardin SE. Abdel-Nour M, et al. Among authors: molinaro r. Science. 2019 Jul 5;365(6448):eaaw4144. doi: 10.1126/science.aaw4144. Science. 2019. PMID: 31273097 Free PMC article.
Schistosomal-derived lysophosphatidylcholine triggers M2 polarization of macrophages through PPARγ dependent mechanisms.
Assunção LS, Magalhães KG, Carneiro AB, Molinaro R, Almeida PE, Atella GC, Castro-Faria-Neto HC, Bozza PT. Assunção LS, et al. Among authors: molinaro r. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Feb;1862(2):246-254. doi: 10.1016/j.bbalip.2016.11.006. Epub 2016 Nov 15. Biochim Biophys Acta Mol Cell Biol Lipids. 2017. PMID: 27871882