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The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine.
Cell Metab. 2021 May 4;33(5):905-922.e6. doi: 10.1016/j.cmet.2021.03.025. Epub 2021 Apr 21.
Cell Metab. 2021.
PMID: 33887198
Free PMC article.
Regulation of metabolic health by dietary histidine in mice.
Flores V, Spicer AB, Sonsalla MM, Richardson NE, Yu D, Sheridan GE, Trautman ME, Babygirija R, Cheng EP, Rojas JM, Yang SE, Wakai MH, Hubbell R, Kasza I, Tomasiewicz JL, Green CL, Dantoin C, Alexander CM, Baur JA, Malecki KC, Lamming DW.
Flores V, et al. Among authors: wakai mh.
J Physiol. 2023 Jun;601(11):2139-2163. doi: 10.1113/JP283261. Epub 2022 Sep 27.
J Physiol. 2023.
PMID: 36086823
Free PMC article.
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Hypothalamic mTORC2 is essential for metabolic health and longevity.
Chellappa K, Brinkman JA, Mukherjee S, Morrison M, Alotaibi MI, Carbajal KA, Alhadeff AL, Perron IJ, Yao R, Purdy CS, DeFelice DM, Wakai MH, Tomasiewicz J, Lin A, Meyer E, Peng Y, Arriola Apelo SI, Puglielli L, Betley JN, Paschos GK, Baur JA, Lamming DW.
Chellappa K, et al. Among authors: wakai mh.
Aging Cell. 2019 Oct;18(5):e13014. doi: 10.1111/acel.13014. Epub 2019 Aug 1.
Aging Cell. 2019.
PMID: 31373126
Free PMC article.
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Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension.
Yu D, Tomasiewicz JL, Yang SE, Miller BR, Wakai MH, Sherman DS, Cummings NE, Baar EL, Brinkman JA, Syed FA, Lamming DW.
Yu D, et al. Among authors: wakai mh.
Cell Rep. 2019 Oct 1;29(1):236-248.e3. doi: 10.1016/j.celrep.2019.08.084.
Cell Rep. 2019.
PMID: 31577953
Free PMC article.
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