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Year Number of Results
2005 1
2006 3
2007 2
2008 3
2012 1
2014 1
2015 3
2016 1
2017 5
2018 2
2019 8
2020 5
2021 1
2022 7
2023 2
2024 0

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41 results

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Page 1
Myeloperoxidase Inhibition Reverses Biomarker Profiles Associated With Clinical Outcomes in HFpEF.
Michaëlsson E, Lund LH, Hage C, Shah SJ, Voors AA, Saraste A, Redfors B, Grove EL, Barasa A, Richards AM, Svedlund S, Lagerström-Fermér M, Gabrielsen A, Garkaviy P, Gan LM, Lam CSP. Michaëlsson E, et al. JACC Heart Fail. 2023 Jul;11(7):775-787. doi: 10.1016/j.jchf.2023.03.002. Epub 2023 May 3. JACC Heart Fail. 2023. PMID: 37140510 Free article. Clinical Trial.
Association of epicardial adipose tissue with proteomics, coronary flow reserve, cardiac structure and function, and quality of life in heart failure with preserved ejection fraction: insights from the PROMIS-HFpEF study.
Venkateshvaran A, Faxen UL, Hage C, Michaëlsson E, Svedlund S, Saraste A, Beussink-Nelson L, Fermer ML, Gan LM, Tromp J, Lam CSP, Shah SJ, Lund LH. Venkateshvaran A, et al. Among authors: michaelsson e. Eur J Heart Fail. 2022 Dec;24(12):2251-2260. doi: 10.1002/ejhf.2709. Epub 2022 Oct 20. Eur J Heart Fail. 2022. PMID: 36196462 Free PMC article.
Rationale and design of ENDEAVOR: A sequential phase 2b-3 randomized clinical trial to evaluate the effect of myeloperoxidase inhibition on symptoms and exercise capacity in heart failure with preserved or mildly reduced ejection fraction.
Lund LH, Lam CSP, Pizzato PE, Gabrielsen A, Michaëlsson E, Nelander K, Ericsson H, Holden J, Folkvaljon F, Mattsson A, Collén A, Aurell M, Whatling C, Baldus S, Drelich G, Goudev A, Merkely B, Bergh N, Shah SJ. Lund LH, et al. Among authors: michaelsson e. Eur J Heart Fail. 2023 Sep;25(9):1696-1707. doi: 10.1002/ejhf.2977. Epub 2023 Aug 22. Eur J Heart Fail. 2023. PMID: 37470101 Clinical Trial.
Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes.
Ramachandra CJA, Kp MMJ, Chua J, Hernandez-Resendiz S, Liehn EA, Knöll R, Gan LM, Michaëlsson E, Jonsson MKB, Ryden-Markinhuhta K, Bhat RV, Fritsche-Danielson R, Lin YH, Sadayappan S, Tang HC, Wong P, Shim W, Hausenloy DJ. Ramachandra CJA, et al. Among authors: michaelsson e. Cardiovasc Res. 2022 Jan 29;118(2):517-530. doi: 10.1093/cvr/cvab077. Cardiovasc Res. 2022. PMID: 33705529 Free PMC article.
Therapeutic Targeting of Myeloperoxidase Attenuates NASH in Mice.
Koop AC, Thiele ND, Steins D, Michaëlsson E, Wehmeyer M, Scheja L, Steglich B, Huber S, Schulze Zur Wiesch J, Lohse AW, Heeren J, Kluwe J. Koop AC, et al. Among authors: michaelsson e. Hepatol Commun. 2020 Jul 29;4(10):1441-1458. doi: 10.1002/hep4.1566. eCollection 2020 Oct. Hepatol Commun. 2020. PMID: 33024915 Free PMC article.
Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction.
Inghardt T, Antonsson T, Ericsson C, Hovdal D, Johannesson P, Johansson C, Jurva U, Kajanus J, Kull B, Michaëlsson E, Pettersen A, Sjögren T, Sörensen H, Westerlund K, Lindstedt EL. Inghardt T, et al. Among authors: michaelsson e. J Med Chem. 2022 Sep 8;65(17):11485-11496. doi: 10.1021/acs.jmedchem.1c02141. Epub 2022 Aug 25. J Med Chem. 2022. PMID: 36005476 Free PMC article.
Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase.
Klinke A, Berghausen E, Friedrichs K, Molz S, Lau D, Remane L, Berlin M, Kaltwasser C, Adam M, Mehrkens D, Mollenhauer M, Manchanda K, Ravekes T, Heresi GA, Aytekin M, Dweik RA, Hennigs JK, Kubala L, Michaëlsson E, Rosenkranz S, Rudolph TK, Hazen SL, Klose H, Schermuly RT, Rudolph V, Baldus S. Klinke A, et al. Among authors: michaelsson e. JCI Insight. 2018 Jun 7;3(11):e97530. doi: 10.1172/jci.insight.97530. eCollection 2018 Jun 7. JCI Insight. 2018. PMID: 29875311 Free PMC article.
Protective Effects of Therapeutic Neutrophil Depletion and Myeloperoxidase Inhibition on Left Ventricular Function and Remodeling in Myocardial Infarction.
Guthoff H, Hof A, Klinke A, Maaß M, Konradi J, Mehrkens D, Geißen S, Nettersheim FS, Braumann S, Michaelsson E, Nies RJ, Lee S, Redzinski MC, Peters VBM, Nemade HN, von Stein P, Winkels H, Rudolph V, Baldus S, Adam M, Mollenhauer M. Guthoff H, et al. Among authors: michaelsson e. Antioxidants (Basel). 2022 Dec 24;12(1):33. doi: 10.3390/antiox12010033. Antioxidants (Basel). 2022. PMID: 36670895 Free PMC article.
41 results