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Page 1
Genomic screening reveals ubiquitin-like modifier activating enzyme 1 as a potent and druggable target in c-MYC-high triple negative breast cancer models.
PNAS Nexus. 2022 Oct 11;1(5):pgac232. doi: 10.1093/pnasnexus/pgac232. eCollection 2022 Nov.
PNAS Nexus. 2022.
PMID: 36712364
Free PMC article.
PI3Kβ is selectively required for growth factor-stimulated macropinocytosis.
Salloum G, Jakubik CT, Erami Z, Heitz SD, Bresnick AR, Backer JM.
Salloum G, et al. Among authors: jakubik ct.
J Cell Sci. 2019 Aug 16;132(16):jcs231639. doi: 10.1242/jcs.231639.
J Cell Sci. 2019.
PMID: 31409694
Free PMC article.
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PIP3 abundance overcomes PI3K signaling selectivity in invadopodia.
Jakubik CT, Weckerly CC, Hammond GRV, Bresnick AR, Backer JM.
Jakubik CT, et al.
FEBS Lett. 2022 Feb;596(4):417-426. doi: 10.1002/1873-3468.14273. Epub 2022 Jan 12.
FEBS Lett. 2022.
PMID: 34990021
Free PMC article.
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Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination.
Ham J, Costa C, Sano R, Lochmann TL, Sennott EM, Patel NU, Dastur A, Gomez-Caraballo M, Krytska K, Hata AN, Floros KV, Hughes MT, Jakubik CT, Heisey DA, Ferrell JT, Bristol ML, March RJ, Yates C, Hicks MA, Nakajima W, Gowda M, Windle BE, Dozmorov MG, Garnett MJ, McDermott U, Harada H, Taylor SM, Morgan IM, Benes CH, Engelman JA, Mossé YP, Faber AC.
Ham J, et al. Among authors: jakubik ct.
Cancer Cell. 2016 Feb 8;29(2):159-72. doi: 10.1016/j.ccell.2016.01.002.
Cancer Cell. 2016.
PMID: 26859456
Free PMC article.
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PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kα Inhibitors in Breast Cancer.
Costa C, Wang Y, Ly A, Hosono Y, Murchie E, Walmsley CS, Huynh T, Healy C, Peterson R, Yanase S, Jakubik CT, Henderson LE, Damon LJ, Timonina D, Sanidas I, Pinto CJ, Mino-Kenudson M, Stone JR, Dyson NJ, Ellisen LW, Bardia A, Ebi H, Benes CH, Engelman JA, Juric D.
Costa C, et al. Among authors: jakubik ct.
Cancer Discov. 2020 Jan;10(1):72-85. doi: 10.1158/2159-8290.CD-18-0830. Epub 2019 Oct 8.
Cancer Discov. 2020.
PMID: 31594766
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Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer.
Costa C, Ebi H, Martini M, Beausoleil SA, Faber AC, Jakubik CT, Huang A, Wang Y, Nishtala M, Hall B, Rikova K, Zhao J, Hirsch E, Benes CH, Engelman JA.
Costa C, et al. Among authors: jakubik ct.
Cancer Cell. 2015 Jan 12;27(1):97-108. doi: 10.1016/j.ccell.2014.11.007. Epub 2014 Dec 24.
Cancer Cell. 2015.
PMID: 25544637
Free PMC article.
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Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer.
Faber AC, Farago AF, Costa C, Dastur A, Gomez-Caraballo M, Robbins R, Wagner BL, Rideout WM 3rd, Jakubik CT, Ham J, Edelman EJ, Ebi H, Yeo AT, Hata AN, Song Y, Patel NU, March RJ, Tam AT, Milano RJ, Boisvert JL, Hicks MA, Elmiligy S, Malstrom SE, Rivera MN, Harada H, Windle BE, Ramaswamy S, Benes CH, Jacks T, Engelman JA.
Faber AC, et al. Among authors: jakubik ct.
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1288-96. doi: 10.1073/pnas.1411848112. Epub 2015 Mar 3.
Proc Natl Acad Sci U S A. 2015.
PMID: 25737542
Free PMC article.
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