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Page 1
Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives.
Khomutov M, Hyvönen MT, Simonian A, Formanovsky AA, Mikhura IV, Chizhov AO, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA, Khomutov AR. Khomutov M, et al. Among authors: simonian a. J Med Chem. 2019 Dec 26;62(24):11335-11347. doi: 10.1021/acs.jmedchem.9b01666. Epub 2019 Dec 13. J Med Chem. 2019. PMID: 31765147 Free PMC article.
Novel convenient synthesis of biologically active esters of hydroxylamine.
Khomutov MA, Mandal S, Weisell J, Saxena N, Simonian AR, Vepsalainen J, Madhubala R, Kochetkov SN. Khomutov MA, et al. Among authors: simonian ar. Amino Acids. 2010 Feb;38(2):509-17. doi: 10.1007/s00726-009-0410-0. Epub 2009 Dec 8. Amino Acids. 2010. PMID: 19997759
Novel agmatine analogue, gamma-guanidinooxypropylamine (GAPA) efficiently inhibits proliferation of Leishmania donovani by depletion of intracellular polyamine levels.
Singh S, Jhingran A, Sharma A, Simonian AR, Soininen P, Vepsalainen J, Khomutov AR, Madhubala R. Singh S, et al. Among authors: simonian ar. Biochem Biophys Res Commun. 2008 Oct 10;375(1):168-72. doi: 10.1016/j.bbrc.2008.07.143. Epub 2008 Aug 8. Biochem Biophys Res Commun. 2008. PMID: 18692480
Methylated polyamines as research tools.
Khomutov AR, Weisell J, Khomutov MA, Grigorenko NA, Simonian AR, Häkkinen MR, Keinänen TA, Hyvönen MT, Alhonen L, Kochetkov SN, Vepsäläinen J. Khomutov AR, et al. Among authors: simonian ar. Methods Mol Biol. 2011;720:449-61. doi: 10.1007/978-1-61779-034-8_29. Methods Mol Biol. 2011. PMID: 21318892