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Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma.
Borgenvik A, Holmberg KO, Bolin S, Zhao M, Savov V, Rosén G, Hutter S, Garancher A, Rahmanto AS, Bergström T, Olsen TK, Mainwaring OJ, Sattanino D, Verbaan AD, Rusert JM, Sundström A, Bravo MB, Dang Y, Wenz AS, Richardson S, Fotaki G, Hill RM, Dubuc AM, Kalushkova A, Remke M, Čančer M, Jernberg-Wiklund H, Giraud G, Chen X, Taylor MD, Sangfelt O, Clifford SC, Schüller U, Wechsler-Reya RJ, Weishaupt H, Swartling FJ. Borgenvik A, et al. Among authors: rosen g. Cancer Res. 2022 Dec 16;82(24):4586-4603. doi: 10.1158/0008-5472.CAN-22-2108. Cancer Res. 2022. PMID: 36219398 Free PMC article.
ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors.
Mainwaring OJ, Weishaupt H, Zhao M, Rosén G, Borgenvik A, Breinschmid L, Verbaan AD, Richardson S, Thompson D, Clifford SC, Hill RM, Annusver K, Sundström A, Holmberg KO, Kasper M, Hutter S, Swartling FJ. Mainwaring OJ, et al. Among authors: rosen g. Nat Commun. 2023 Mar 3;14(1):1221. doi: 10.1038/s41467-023-36847-9. Nat Commun. 2023. PMID: 36869047 Free PMC article.
Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy.
Čančer M, Hutter S, Holmberg KO, Rosén G, Sundström A, Tailor J, Bergström T, Garancher A, Essand M, Wechsler-Reya RJ, Falk A, Weishaupt H, Swartling FJ. Čančer M, et al. Among authors: rosen g. Cell Stem Cell. 2019 Dec 5;25(6):855-870.e11. doi: 10.1016/j.stem.2019.10.005. Epub 2019 Nov 27. Cell Stem Cell. 2019. PMID: 31786016 Free PMC article.
FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma.
Suryo Rahmanto A, Savov V, Brunner A, Bolin S, Weishaupt H, Malyukova A, Rosén G, Čančer M, Hutter S, Sundström A, Kawauchi D, Jones DT, Spruck C, Taylor MD, Cho YJ, Pfister SM, Kool M, Korshunov A, Swartling FJ, Sangfelt O. Suryo Rahmanto A, et al. Among authors: rosen g. EMBO J. 2016 Oct 17;35(20):2192-2212. doi: 10.15252/embj.201693889. Epub 2016 Sep 13. EMBO J. 2016. PMID: 27625374 Free PMC article.